CUSTOM CLINICAL SERVICES
Progesterone, in recent history was omitted in
women with Hysterectomies. The thought process
being that Progesterone ( actually Progestins in these cases) only function was thought to be to "prime" the uterus for implantation. There are 3 main problems with this philosophy, First: Progesterone WAS NOT used instead it was MedroxyProgesterone, second, recent studies have shown multiple benefits both psychological and physiological. First, mentally, Progesterone elevates the GABA neurotransmitter, which provides a calming effect and is believed to be one of the main factors in preventing PMS. An interesting side note is that there is a type of pre-menstrual seizure directly related to the precipitous drop in Progesterone resposible for iducing menses. Second, Progesterone has been shown to elevate Seratonin, therefore, behaving like a natural SSRI in many women. This is one of the primary reasons Progesterone has been effectively treat Post-partum depression in some women. Third, Progesterone not only blunts bone resorption like Estrogen, but also, has been shown to increase the number of osteoblasts in post-menopausal women.
Interestingly, the synthetic Progesterones or Progestins have not been shown to demonstate these benefits. Furthermore, the studies showing that PROGESTINS are causative in certain cancers including breast cancer are not the same in Bio-Identical Progesterone. Studies that were re-evaluated with a separation between the two groups show that Natural Progesterone either does not changge the cancer rate OR ACTUALLY LOWERS THE RISK. (see studies section at the end of this website.
In actual practice over the last 25 years, we have seen Bio-Identical Progesterone effectively treat insomnia, mood-swings, PMS, migraine headaches, and osteopenia/oseteoporosis.
Q) WHAT ARE BIOIDENTICAL HORMONES ?
A) This has alwalys struck me as an odd question. Bio-Identical means atom for atom, molecule for molecule they are "clones". In Medical School, when studying the Endocrine system these are what was studied. Drug companies modify these basic hormones in order to achieve a patentable molecule. So Estradiol becomes Ethinyl-Estradiol or Premarin (conjugated estrogens). Progesterone becomes MedroxyProgesterone or Norethindrone. One only need to look at the doses of these medications to "see" the difference. Progesterone or Brand Name Prometrium which comes in doses of 100mg and 200mg oil capsules while MedroxyProgesterone comes in strengths of 2mg,5mg and 10mg. Metabolically, they are processed differently and have differently.
Q) WHERE DO THEY COME FROM ?
A) In the body hormones are derived from Cholesterol first forming Pregnenolone. From Pregnenolone, all other hormones are derived via enzymatic processes. In Manufacturing, the starting point is either the soy or yam plant. These plants are choes because they have a very similar 3 ring structure to Cholesterol and it takes very few manipulations to form the target molecule.
Q) ARE THERE ANY DOUBLE BLIND STUDIES ?
A) Again, I find this question VERY odd. The short answer is yes. The long answer is another question...Does it matter? These EXACT hormones have been present in Men and Women since the dawn of Man and perform all the necessary functions just fine. We don't need studies to KNOW they work. What we do need is highly absorbable, consistent dosage forms to provide adequate levels. We at CCS have worked very closely with certain Pharmacies over 20 years to produce such a dosage form that is consistent,highly absorbable and has stable Pharmacokinetics.
Q) ARE THEY FDA APPROVED ?
A) Again, The Compounding process is NOT GOVERNED by the FDA, so they can not be "FDA APPROVED", however, ALL INGREDIENTS ARE FDA APPROVED AS ARE THE FACILITIES WHICH MUST BE INSPECTED BEFORE THEY CAN BE APPROVED SUPPLIERS.